If you are taking the course for credit or for a letter grade, you must complete the assignment.
Write a 2 to 3 page summary of a scientific research article on a topic related to the course.
You may write your summary on one of the research articles in the course reader, or choose a research article from the scientific literature.
In your summary, describe the background or justification for the research, the objective of the research, the methods used, the results, the conclusions, and your own thoughts on the validity and utility of the results.
Hand in a copy of the article with your summary.
1. Osborne, TB.
The Effect of retardation of growth upon the breeding period and duration of life of rats.
2. Mattison JA, Lane MA, Roth GS, Ingram DK.
Calorie restriction in rhesus monkeys.
3. Roth GS, Lane MA, et al.
Biomarkers of caloric restriction may predict longevity in humans.
4. Mair W, Goymer P, Pletcher SD, Partridge L.
Demography of dietary restriction and death in Drosophila.
5. Anson RM, Guo Z, et al
Intermittent fasting dissociates beneficial effects of dietary restriction on glucose metabolism and neuronal resistance to injury from calorie intake.
6. Weindruch R, Kayo T, Lee CK, Prolla TA.
Gene expression profiling of aging using DNA microarrays.
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7. Lane MA, Ingram DK, Roth GS.
The serious search for an anti-aging pill.
8. Zimmerman JA, Malloy V, Krajcik R, Orentreich N.
Nutritional control of aging.
9. Guarente L, Kenyon C.
Genetic pathways that regulate ageing in model organisms.
10. Kenyon C, Chang J, Gensch E, Rudner A, Tabtiang R.
A C. elegans mutant that lives twice as long as wild type.
11. Kimura KD, Tissenbaum HA, Liu Y, Ruvkun G.
daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans.
12. Murphy CT, McCarroll SA, et al
Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans.
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13. Lin YJ, Seroude L, Benzer S.
Extended life-span and stress resistance in the Drosophila mutant methuselah.
14. Rogina B, Reenan RA, Nilsen SP, Helfand SL.
Extended life-span conferred by cotransporter gene mutations in Drosophila.
15. Tatar M, Kopelman A, et al
A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function.
16. Holzenberger M, Dupont J, et al
IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice.
17. Fabrizio P, Liou LL, et al
SOD2 functions downstream of Sch9 to extend longevity in yeast.
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18. Orr WC, Sohal RS.
Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster.
19. Orr WC, Sohal RS
Does overexpression of Cu,Zn-SOD extend life span in Drosophila melanogaster?
20. Parkes TL, Elia AJ, et al
Extension of Drosophila lifespan by overexpression of human SOD1 in motorneurons.
21. Phillips JP, Parkes TL, Hilliker AJ.
Targeted neuronal gene expression and longevity in Drosophila.
22. Melov S, Ravenscroft J, Malik S, et al
Extension of life-span with superoxide dismutase/catalase mimetics.
23. Liu R, Liu IY, Bi X, et al Reversal of age-related learning deficits and brain oxidative stress in mice with superoxide dismutase/catalase mimetics.
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24. Bayne AC, Sohal RS.
Effects of superoxide dismutase/catalase mimetics on life span and oxidative stress resistance in the housefly, Musca domestica.
25. Lambert AJ, Merry BJ.
Effect of caloric restriction on mitochondrial reactive oxygen species production and bioenergetics: reversal by insulin.
26. Larsen PL, Clarke CF.
Extension of life-span in Caenorhabditis elegans by a diet lacking coenzyme Q.
27. Asencio C, Rodriguez-Aguilera JC, et al
Silencing of ubiquinone biosynthesis genes extends life span in Caenorhabditis elegans.
28. Howitz KT, Bitterman KJ, et al
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan.
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