Michael G. Walker Ph.D.

Consulting and Training

Biostatistics, Biotechnology and Bioinformatics for
Pharmaceutical and Biotechnology Research and Development

Curriculum Vitae - Education I Employment I Professional Activities I Patents I Publications

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Education

Ph.D., Medical Computer Science, Stanford University, 1992.

B.Sc., Queen’s University, Canada, 1975.

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Employment

Consulting Professor

Department of Medicine Stanford University 1995 to present.

Teaching courses in biostatistics, bioinformatics and biotechnology.

Graduate student advisor and dissertation committee member.

Invited Lecturer

Harvard School of Medicine - U.S. Patent and Trademark Office - Beijing Genome Institute - European Bioinformatics Institute

President of Walker Bioscience

Biostatistics and bioinformatics consulting. 1995 to present.

Statistics and Bioinformatics Consulting for biotechnology and pharmaceutical companies in genomics and drug development.

Senior Research Scientist

Department of Medicine, Stanford University. 1992 to 1995.

Awarded

Research Career Development Award from the National Center for Human Genome Research.

Developed statistical methods for DNA analysis.

Ph.D. Student

Medical Computer Science, Stanford University. 1987-1992.

Dissertation: Probability estimation for classification trees and DNA sequence analysis.

Research Scientist

Computer Science Department, Stanford University. 1982-1987.

Developed systems for automated statistical analysis of clinical data & medical images.

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Referee

Computers in Biomedical Research - Bioinformatics - IEEE Computer - Intelligent Systems for Molecular Biology - Pacific Symposium on Biocomputing . . .

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Statistician for FDA-approved New Drug Applications

Ganciclovir 040 Study Team.

“A randomized, double-blind study of the efficacy and safety of oral ganciclovir for the prevention of CMV disease in liver transplant patients. Roche. 1996.

Ganciclovir 1654 Study Team.

“A randomized, double-blind study of the efficacy and safety of oral ganciclovir for the prevention of CMV disease people infected with the human immunodeficiency virus. Syntex. 1996.

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Patents

Neural synapse associated genes. Incyte Genomics 2002.

SPARC-related proteins. Incyte Genomics 2002.

RAS association domain containing protein. Incyte Genomics 2002.

Ovarian cancer associated genes. Incyte Genomics 2001.

Diagnostic markers for breast cancer. Incyte Genomics 2001.

Pulmonary surfactant associated genes. Incyte Genomics 2001.

Methods for analyzing gene expression patterns. Incyte Genomics 2001.

Genes induced by retinoic acid. Incyte Genomics 2001.

Ankyrin repeat domain 2 protein variant. Incyte Genomics 2001.

Growth-related inflammatory and immune response protein. Incyte Genomics 2000.

Cell-cycle associated genes. Incyte Genomics 2000.

Bone remodeling genes. Incyte Genomics 2000.

SPARC-related proteins. Incyte Genomics 2000.

Placental steroid-synthesis associated genes. Incyte Genomics 2000.

Xin-related gene. Incyte Genomics 2000.

SST: An algorithm for searching sequence databases in logarithmic time. Incyte 1999.

Cardiac muscle-associated genes. Incyte Pharmaceuticals 1999.

Atherosclerosis-associated genes. Incyte Pharmaceuticals 1999.

Genes associated with diseases of the colon. Incyte Pharmaceuticals 1999.

Genes associated with diseases of the kidney. Incyte Pharmaceuticals 1999.

Corticosteroid-synthesis associated genes. Incyte Pharmaceuticals 1998.

Insulin-synthesis genes. Incyte Pharmaceuticals 1998.

Inflammation-associated genes. Incyte Pharmaceuticals 1998.

Prostate-cancer associated genes. Incyte Pharmaceuticals 1998.

Genes associated with neurotransmitter processing. Incyte Pharmaceuticals 1998.

Matrix remodeling genes. Incyte Pharmaceuticals 1998.

Composition for the detection of cancer gene expression. Incyte Pharmaceuticals 1997.

Computer-aided probability base-calling for arrays of nucleic acid probes on chips. Affymetrix 1996.

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Publications

Paik, S, Shak, S, Tang, G., Kim, C., Baker, J., Cronin, M., Baehner, F.L., Walker, M.G., Watson, D., Park, T., Hiller, WT., Fisher, E.R., Wickerham, D.L., Bryant, J., and Wolmark, N. - (view pdf)

A Multigene Assay to Predict Recurrence of Tamoxifen-Treated, Node-Negative Breast Cancer.

New England Journal of Medicine, 2004,351:2817-26.

Stuve, L.L., Stewart, E.A., Walker, M.G., et al.

Evidence for a rarely expressed gene population from analysis of Chromosome 21.

Submitted.

Spek, P.J., Kremer, A., Murry L., and Walker, M.G. - (view pdf)

Are gene expression microarray analyses reliable? A review of studies of retinoic acid responsive genes.

Genomics, Proteomics, and Bioinformatics. February 2003, 1:1:9-14.

Zhou, Y., Tang, J., Walker, M.G., et al. - (view pdf)

Gene identification and expression analysis of 86,136 expressed sequence tags (EST) from the rice genome.

Genomics, Proteomics, and Bioinformatics. February 2003, 1:1:26-42.

Walker, M.G. - (view pdf)

Gene expression versus sequence for predicting function: Glia Maturation Factor gamma is not a glia maturation factor.

Genomics, Proteomics, and Bioinformatics. February 2003, 1:1:52-57.

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Walker, M.G., and Volkmuth, W. - (view pdf)

Cell adhesion and matrix remodeling genes identified by co-expression analysis.

Gene Function and Disease. 2002, 3(3-4):109-112.

Giladi, E., Walker, M.G., Wang, J.Z., and Volkmuth, W. - (view pdf)

SST: an algorithm for finding near-exact sequence matches in time proportional to the logarithm of the database size.

Bioinformatics. 2002, 18(6):873-7.

Bloch, D., Olshen, R.A., and Walker, M.G.

Probability estimation for classification trees.

Journal of Computational and Graphical Statistics. 2002, 11(2): 263-288.

Walker, M.G. - (view pdf)

Z39Ig is co-expressed with activated macrophage genes.

Biochimica et Biophysica Acta. 2002, Apr 12;1574(3):387-90.

Wong, S.L., and Walker, M.G. - (view pdf)

A bioinformatics approach to identifying fetal development genes.

Gene Function and Disease. 2001, 2:5-6:221-225

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Walker, M.G. - (view pdf)

Pharmaceutical target identification by gene expression analysis.

Mini-Reviews in Medicinal Chemistry. 2001, 197-205.

Walker, M.G. - (view pdf)

Drug target discovery by gene expression analysis: cell cycle genes.

Current Cancer Drug Targets. 2001, 1:73-83.

Walker, M.G., Volkmuth, W, Sprinzak,A, Hodgson,D, and Klingler, T.M. - (view pdf)

Prediction of gene function by genome-scale expression analysis: prostate-cancer associated genes.

Genome Research. December 1999. v. 9, no. 12, pp. 1198-1203.

Walker, M.G., Volkmuth,W, and Klingler, T.M. - (view pdf)

Pharmaceutical target discovery using Guilt-By-Association: schizophrenia and Parkinson’s disease genes.

Intelligent Systems in Molecular Biology, pp. 282-286, 1999.

Oral Ganciclovir International Transplantation Study Group.

Randomized trial of efficacy and safety of oral ganciclovir in the prevention of cytomegalovirus disease in liver-transplant recipients.

Lancet, 350:9093:1729-1733, 1997.

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Pescovitz, M., Gane, E., Walker, M.G., et al.

Efficacy and safety of oral ganciclovir in the prevention of cytomegalovirus (CMV) disease in liver-transplant recipients.

1996 Interscience Conference on Antimicrobial Agents and Chemotherapy, Dallas, TX.

Ohno-Machado, L., Walker, M.G., and Musen, M.A. - (view pdf)

Hierarchical neural network for survival analysis.

1995 World Conference on Medical Informatics.

Walker, M.G., and Olshen, R.A.

Probability estimation for biomedical classification problems.

1992 Symposium on Computer Applications for Medical Care, pp 451-455.

Walker, M.G., and Wiederhold, G.

Acquisition and validation of knowledge from data.

Chapter 17, pp 415-428 in Intelligent Systems, Z.W. Ras and M. Zemankova, Editors. Ellis Horwood, New York, 1990.

Walker, M.G., and Brutlag, D.L.

Nonparametric sequence classification.

American Medical Informatics Association Education and Research Conference, 1990.

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Walker, M.G., and Brutlag. D.

Computer tools for identifying signals in DNA sequences.

International Symposium and Workshop on Macromolecules, Genes, and Computers. New Hampshire, 1989.

DeLaPaz, R., Bernstein, R., Chang, P., Hanson, W., and Walker, M.G.

Approximate fuzzy c-means (AFCM) cluster analysis of medical magnetic resonance image (MRI) data.

International Conference on Pattern Recognition, Beijing, 1988.

Walker, M.G.

Expert systems in geological exploration: can they be cost effective?

Geobyte, pp 18-23, 1988.

DeLaPaz, R., Bernstein, R., Hanson, W., and Walker, M.G.

Approximate fuzzy c-means cluster analysis of medical MRI images.

Computers in Medical Education, 1988.

DeZegher-Geets, I., Freeman, A.G., Walker, M.G., Blum, R.L., and Wiederhold, G.

Intelligent summarization and display of on-line medical records.

M.D. Computing, 5:3:38-54, 1988.

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Wiederhold, G., Walker, M.G., Blum, R.L., Downs, S.M., and DeZegher-Geets, I.

Acquisition of medical knowledge from medical records.

Proceedings of Benutzergruppenseminar Medizin Systems 87, Munich, Germany, 1987.

eZegher-Geets, I., Freeman, A.G., Walker, M.G., Blum, R.L., and Wiederhold, G.D.

Computer-aided summarization of a time-oriented medical database.

Proceedings of the Third International Conference, Institute for Medical Record Economics, 1987.

Wiederhold, G., Walker, M.G., et al.xx

KSYS: an architecture for integrating databases and knowledge bases.

In Technical Opinions Regarding Knowledge Based Integrated Information Systems Engineering, Gupta, A. and Madnick, S., editors. MIT, 1987.

Walker, M.G.

How feasible is automated discovery?

IEEE Expert, 2:1:70-82,1987.

Wiederhold, G., Blum, R.L., and Walker, M.G.

An integration of knowledge and data representation.

pp 431-444 in On Knowledge Based Management Systems: integrating artificial intelligence and database technologies. Brodie, Mylopoulos and Schmidt (editors), Springer-Verlag, 1986.

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Blum, R.L., and Walker, M.G.

Lisp as an environment for software design.

Tenth Annual Symposium on Computers in Medical Care, Washington, D.C., 1986.

Walker, M.G., and Blum, R.L.

Towards automated discovery from clinical databases: the RADIX project.

1986 World Conference on Medical Informatics, Washington, D.C.

Downs, S., Walker, M.G., and Blum, R.L.

Automated summaries of patient medical records.

1986 World Conference on Medical Informatics, Washington, D.C., 1986.

Walker, M.G., Blum, R.L., and Fagan, L.M.

Minimycin: a miniature rule-based system.

M.D. Computing, v 2, no 4, 1985.

Walker, M.G., and Blum, R.L.,

An introduction to Lisp.

M.D. Computing, 2: 4:1985.

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Walker, M.G.

Society for Computer Simulation Summer Conference Report.

Canadian Information Processing Society Review, 1979.